疾病医学前沿 | 诊断为中轴型脊柱关节炎的患者的疾病观念和应对策略是否会随时间改变?

摘自:中华风湿
疾病医学前沿 | 诊断为中轴型脊柱关节炎的患者的疾病观念和应对策略是否会随时间改变?
本文图片

诊断为中轴型脊柱关节炎
的患者的疾病观念和
应对策略是否会随时间改变?

的:
尚不清楚当中轴型脊椎关节炎(axSpA)患者疾病活动发生变化时 , 疾病感知和应对策略是否会发生变化 。

法:
应用在SPACE队列中被诊断为axSpA且随访次数≥1次(1年和/或2年)的患者身上 。 混合线性模型用于疾病感知(范围:1-5)、应对(范围:1-4、背痛(NRS:0-10)、健康相关的生活质量(HRQoL范围:0-100(物理) (PCS)和心理成分摘要(MCS))、工作生产力损失(WPL)以及活动障碍(AI , 范围:0-100%) , 以测试它们是否随时间变化 。

果:
【疾病医学前沿 | 诊断为中轴型脊柱关节炎的患者的疾病观念和应对策略是否会随时间改变?】在基线上 , 150名axSpA患者(平均年龄30.4岁 , 女性51% , HLA-B27 + 65%)的平均(SD)VAS背痛为4.0(2.5) , PCS为28.8(14.0) , MCS为47.8(12.4), WPL为34.1%(29.8) , AI为38.7%(27.9) 。 两年多来 , 在ASDAS低疾病活动度(从39%到68%) , 背痛(-1.5(2.2)) , AI(-14.4%(27.2)) ,PCS(11.1(13.3))和WPL(-15.3%(28.7)) , 但MCS不变(0.7(13.9) , p = 0.201) 。 相反 , 在两年的时间内 , 患者对疾病的看法和应对策略没有改变 。 例如 , 在两年的时间里 , 患者认为他们的疾病有严重的“后果”(2.8(0.9)) , 并且对疾病有消极的情绪(例如感到沮丧或恐惧)(“情绪表征” , 2.5(0.8)) 。 患者最常通过认知疼痛来应对疼痛(“舒适感” , 2.8(0.6)) , 并通过保持乐观来应对身体的限制(“乐观” , 2.9(0.7)) 。

论:
过去两年中 , 虽然背痛、疾病活动和健康结果明显改善 , 但疾病观念和应对策略仍然非常稳定 。
原   文
Do illness perceptions and coping strategies change over time in patients recently diagnosed with axial spondyloarthritis?
Objective
It is unknown if in axial spondyloarthritis (axSpA) patients illness perceptions and coping strategies change when disease activity changes.
Methods
Patients diagnosed with axSpA and ≥1 follow-up visit (1 and/or 2 year(s)) in the SPACE-cohort were included. Mixed linear models were used for illness perceptions (range:1-5), coping (range:1-4), back pain (NRS:0-10), health-related quality of life (HRQoL range:0-100 (physical (PCS) and mental component summary (MCS)), work productivity loss (WPL), and activity impairment (AI, range:0-100%), separately, to test if they changed over time.
Results
At baseline, 150 axSpA patients (mean age 30.4 years,51% female,65% HLA-B27+) had a mean (SD) VAS back pain of 4.0(2.5), PCS of 28.8(14.0), MCS of 47.8(12.4), WPL of 34.1%(29.8) and AI of 38.7%(27.9). Over two years, clinically and statistically significant improvements were seen in the proportion of patients with ASDAS low disease activity (from 39% to 68%), back pain (-1.5(2.2)), AI (-14.4%(27.2)), PCS (11.1(13.3)) and WPL (-15.3%(28.7)), but MCS did not change (0.7(13.9),p=0.201). In contrast, illness perceptions and coping strategies did not change over a period of two years. For example, at two years patients believed that their illness had severe ‘consequences’ (2.8(0.9)) and they had negative emotions (e.g. feeling upset or fear) towards their illness (‘emotional representation’, 2.5(0.8)). Patients most often coped with their pain by putting pain into perspective (‘comforting cognitions’, 2.8(0.6)) and tended to cope with limitations by being optimistic (‘optimism’,2.9(0.7)).


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