医药巨头诺华投资抗纤维化药物，目标可能是新冠肺炎后市场( 三 )
考虑到此次病毒在全球大范围蔓延以及外国的肺炎治理问题 ， 很多无法在轻症阶段对疾病进行介入 ， 全球新冠肺炎重症患者数量会出现大幅的增长 ， 未来肺纤维化患者也会出现相对应的增加 。
所以 ， 诺华在今年投资抗肺纤维化药物可能是一个值得注意的市场信号 。
References:
1. Margadant C, Sonnenberg A. Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healing. EMBO Rep. 2010;11(2):97–105.
2. Bierie B, Moses HL. Transforming growth factor beta (TGF-beta) and inflammation in cancer. Cytokine Growth Factor Rev. 2010;21(1):49–59.
3. https://plan.core-apps.com/tristar_aasld19/abstract/c6412aeabf1621426ae4fd981f59bd66
4. https://pliantrx.com/pliant-therapeutics-reports-positive-results-of-phase-1b-clinical-study-supporting-advancement-of-pln-74809-for-treatment-of-idiopathic-pulmonary-fibrosis/
5. Khalil N, O'Connor R. Idiopathic pulmonary fibrosis: current understanding of the pathogenesis and the status of treatment. CMAJ. 2004;171:153–160.
6. Vannella KM, Moore BB. Viruses as co-factors for the initiation or exacerbation of lung fibrosis. Fibrogenesis Tissue Repair. 2008;1:2.
7. Naik PK, Moore BB. Viral infection and aging as cofactors for the development of pulmonary fibrosis. Expert Rev Respir Med. 2010;4(6):759–771.
8. Daccord C, Maher TM. Recent advances in understanding idiopathic pulmonary fibrosis. F1000Res. 2016;5:F1000 Faculty Rev-1046. Published 2016 May 31.
9. 陆普选, 杨桂林, 余卫业, et al. Imaging follow-up of SARS patients complicated with pulmonary fibrosis SARS 患者合并肺纤维化的影像学随访 [J]. 中国医学影像技术, 2004, 020(012):1901-1903.
10. Hui DS, Joynt GM, Wong KT, Gomersall CD, Li TS, Antonio G, Ko FW, Chan MC, Chan DP, Tong MW, Rainer TH, Ahuja AT, Cockram CS, Sung JJY. Impact of severe acute respiratory syndrome (SARS) on pulmonary function, functional capacity and quality of life in a cohort of survivors. Thorax. 2005;60:401–409.
11. Das KM, Lee EY, Singh R, et al. Follow-up chest radiographic findings in patients with MERS-CoV after recovery. Indian J Radiol Imaging. 2017;27(3):342–349.
12. Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med342: 1334–1349, 2000.
13. Sakai N, Tager AM. Fibrosis of two: Epithelial cell-fibroblast interactions in pulmonary fibrosis. Biochim Biophys Acta. 2013;1832(7):911–921.
14. Wynn TA. Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. J Clin Invest. 2007;117(3):524–529.
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