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中科院最新发现，新冠病毒来源另有出处
中科院最新发现 ， 新冠病毒来源另有出处
改变了氨基酸类型 ， 并有42个(53.17%)氨基酸理化性质都被改变（图3） 。 这些氨基酸类型以及理化性质改变是否会影响新型冠状病毒的活性暂不清楚 ， 需要其他蛋白组学和结构生物学方面的专业人士进行验证 。 本研究是版纳植物园综合保护中心生物多样性研究组的科研人员利用其在系统与演化领域的专长开展的 ， 本研究提到单倍型演化关系分析方法可以结合到传染病学研究中 ， 对于寻找传染源 ， 以及精确的传播和扩散方向能提供非常重要的信息 。 附件： Decoding evolution and transmissions of novel pneumonia coronavirus using the whole genomic data 提交时间： 2020-02-21 作者： Yu, Wen-Bin 1,2 ; Tang, Guang-Da 3,4 ; Zhang, Li 5 ; Corlett, Richard T. 1.2 ; 作者单位： 1.Center for Integrative Conservation, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Mengla, Yunnan 666303, China; 2.Center of Conservation Biology, Core Botanical Gardens, Chinese Academy of Sciences, Mengla, Yunnan 666303, China; 3.Henry Fok College of Biology and Agriculture, Shaoguan University, Shaoguan 512005, China; 4.College of Forestry and Landscape Architecture, South China Agricultural University, Guangzhou 510642, China; 5.Chinese Institute for Brain Research, Beijing 102206, China; 更多0 内容摘要 Background. The outbreak of COVID-19 started in mid-December 2019 in Wuhan, Central China. Up to February 18, 2020, SARS-CoV-2 has infected more than 70,000 people in China, and another 25 countries across five continents. In this study, we used 93 complete genomes of SARS-CoV-2 from the GISAID EpiFluTM database to decode the evolution and human-to-human transmissions of SARS-CoV-2 in the recent two months. Methods. Alignment of coding-regions was conducted haplotype analyses using DnaSP. Substitution sites were analyzed in codon. Evolutionary analysis of haplotypes used NETWORK. Population size changes were estimated using both DnaSP and Arlequin. Expansion date of population size was calculated based on the expansion parameter tau (τ) using the formula t=τ/2u. Findings. Eight coding-regions have 120 substitution sites, including 79 non-synonymous and 40 synonymous substitutions. Forty-two non-synonymous substitutions changed the biochemical property of amino acids. No evident combination was found. Fifty-eight haplotypes were classified as five groups, and 31 haplotypes were found in samples from both China and other countries, respectively. The rooted network suggested H13 and H35 to be ancestral haplotypes, and H1 (and its descendent haplotypes including all samples from the Hua Nan market) was derived H3 haplotype. Population size of SARS-CoV-2 were estimated to have a recent expansion on 6 January 2020, and an early expansion on 8 December 2019. Interpretation. Genomic variations of SARS-CoV-2 are still low in comparisons with published genomes of SARS-CoV and MERS-CoV. Phyloepidemiologic analyses indicated the SARS-CoV-2 source at the Hua Nan market should be imported from other places. The crowded market boosted SARS-CoV-2 rapid circulations in the market and spread it to the whole city in early December 2019. Furthermore, phyloepidemiologic approaches have recovered specific direction of human-to-human transmissions, and the import sources of international infectious cases. 说明 ， 本文依据郁文彬的《版纳植物园基于全基因组数据解析新型冠状病毒的演化和传播》整理 付原始论文链接地址：http://www.chinaxiv.org/abs/202002.00033</p>
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