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奇点网|《科学》：运动能让肝脏释放一种酶，促进神经再生，改善认知( 三 )


据了解 ， Villeda实验室正全力研究Gpld1 ， 以搞清楚Gpld1究竟是如何与其他生化信号系统相互作用 ， 最终发挥有益大脑的作用 。 他们希望通过他们的深入研究 ， 能确定特定的治疗目标 ， 有朝一日让不能运动的人也受惠于运动对大脑的益处 。
参考资料：
[1].Erickson K I, Voss M W, Prakash R S, et al. Exercise training increases size of hippocampus and improves memory[J]. Proceedings of the National Academy of Sciences, 2011, 108(7): 3017-3022.
[2].Maass A, Düzel S, Goerke M, et al. Vascular hippocampal plasticity after aerobic exercise in older adults[J]. Molecular psychiatry, 2015, 20(5): 585-593.
[3].Horowitz A M, Villeda S A. Therapeutic potential of systemic brain rejuvenation strategies for neurodegenerative disease[J]. F1000Research, 2017, 6.
[4].https://science.sciencemag.org/content/369/6500/167
[5].https://www.ucsf.edu/news/2020/07/418041/brain-benefits-exercise-can-be-gained-single-protein
[6].Van Praag H, Shubert T, Zhao C, et al. Exercise enhances learning and hippocampal neurogenesis in aged mice[J]. Journal of Neuroscience, 2005, 25(38): 8680-8685.
[7].Kumar A, Rani A, Tchigranova O, et al. Influence of late-life exposure to environmental enrichment or exercise on hippocampal function and CA1 senescent physiology[J]. Neurobiology of aging, 2012, 33(4): 828. e1-828. e17.
[8].Soto I, Graham L C, Richter H J, et al. APOE stabilization by exercise prevents aging neurovascular dysfunction and complement induction[J]. PLoS Biol, 2015, 13(10): e1002279.
[9].Villeda S A, Luo J, Mosher K I, et al. The ageing systemic milieu negatively regulates neurogenesis and cognitive function[J]. Nature, 2011, 477(7362): 90-94.
[10].Katsimpardi L, Litterman N K, Schein P A, et al. Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors[J]. Science, 2014, 344(6184): 630-634.
[11].Castellano J M, Mosher K I, Abbey R J, et al. Human umbilical cord plasma proteins revitalize hippocampal function in aged mice[J]. Nature, 2017, 544(7651): 488-492.
[12].Villeda S A, Plambeck K E, Middeldorp J, et al. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice[J]. Nature medicine, 2014, 20(6): 659-663.
[13].Maguire G A, Gossner A. Glycosyl phosphatidyl inositol phospholipase D activity in human serum[J]. Annals of clinical biochemistry, 1995, 32(1): 74-78.
奇点网|《科学》：运动能让肝脏释放一种酶，促进神经再生，改善认知
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本文作者 | BioTalker
不运动都对不起科学家的研究成果


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